Molecular diversity and natural products
نویسندگان
چکیده
منابع مشابه
Cholesterol: Biosynthesis, Functional Diversity, Homeostasis and Regulation by Natural Products
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A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.
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In their retrospective analysis of natural product (NP) discovery since the 1940s, Pye et al. (1) observe a gradual decline in the proportion of NPs discovered each year with low similarity to previously known compounds [defined by maximum Tanimoto coefficient (Tc) < 0.4]. Additionally, the authors report that the median maximum Tc for all NPs discovered in a given year has plateaued since the ...
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Natural products have proven to be valuable sources for the identification of new drug candidates, and also as tools for chemical biology and medicinal chemistry research [1]. In fact, if we trace back human history, many natural products have also long been used to treat various human disorders and distinguished by their drug-like properties [2]. To date, tens of thousands of bioactive compoun...
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ژورنال
عنوان ژورنال: Molecular Diversity
سال: 2011
ISSN: 1381-1991,1573-501X
DOI: 10.1007/s11030-011-9315-4